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Febustat 40mg Tablet 1 Strip
Febustat tablets are prescribed for the long-term management of hyperuricemia in individuals with gout. These tablets are not intended for treating asymptomatic hyperuricemia.
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✅ Description:
Febuxostat is a selective, non-purine xanthine oxidase (XO) inhibitor. It works by lowering uric acid levels in the blood by inhibiting the enzyme xanthine oxidase, which converts hypoxanthine into xanthine and subsequently into uric acid. Unlike other treatments, Febuxostat does not interfere with enzymes involved in purine and pyrimidine metabolism at therapeutic doses.
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✔️ Side Effects
Commonly reported side effects include gout flares, abnormal liver function tests, diarrhea, nausea, headache, rash, and swelling. In rare cases, serious hypersensitivity reactions may occur.
✔️ Dosage & Administration
- Standard Dosage: The initial dose is 40 mg once daily. If serum uric acid remains above 6 mg/dL after two weeks, the dose may be increased to 80 mg once daily. If levels are still elevated after 2-4 weeks at 80 mg, the dose may be raised to 120 mg once daily.
- Tumor Lysis Syndrome: The recommended dose is 120 mg once daily, starting two days before chemotherapy and continuing for at least seven days (or up to nine days based on clinical assessment).
- Gout Flares: Flares may occur due to fluctuations in serum uric acid levels, leading to the release of urate deposits. Prophylactic use of NSAIDs or colchicine is advised when starting treatment. If a flare occurs, Febuxostat should not be discontinued but managed concurrently.
- Renal & Hepatic Impairment: No dosage adjustment is needed for patients with mild to moderate kidney or liver dysfunction.
- Pediatric Use: Safety and effectiveness have not been established for individuals under 18 years of age.
✔️ Drug Interactions
- Mercaptopurine/Azathioprine: Not recommended due to Febuxostat's mechanism of action, which may elevate plasma levels of these drugs, leading to toxicity.
- Rosiglitazone/CYP2C8 Substrates: No dosage adjustments required.
- NSAIDs (e.g., Naproxen, Probenecid): These may theoretically affect Febuxostat elimination, but co-administration is generally safe.
- Inducers of Glucuronidation: Potent inducers may accelerate Febuxostat metabolism, reducing effectiveness. Serum uric acid levels should be monitored.
- Colchicine, Indomethacin, Hydrochlorothiazide, Warfarin: Co-administration does not require dosage adjustments.
- Antacids: Taking antacids containing magnesium and aluminum hydroxide may delay Febuxostat absorption, but it does not significantly affect overall drug levels.
✔️ Contraindications
Febuxostat should not be used in patients taking azathioprine, mercaptopurine, or theophylline.
✔️ Pregnancy & Lactation
- Pregnancy (Category C): There is insufficient data on its safety during pregnancy. Febuxostat should only be used if the potential benefits outweigh the risks.
- Breastfeeding: It is unknown whether Febuxostat passes into breast milk, so caution is advised when prescribing to nursing mothers.
✔️ Precautions & Warnings
- Gout Flares: Increased flare-ups are common when initiating therapy. Preventive use of NSAIDs or colchicine for up to six months may be beneficial.
- Cardiovascular Risk: Some studies indicate a higher incidence of heart attacks and strokes in patients taking Febuxostat compared to allopurinol. Monitor for symptoms.
- Liver Function: Periodic liver enzyme monitoring is recommended, as elevated transaminase levels have been observed.
✔️ Storage Conditions
Store below 30°C, away from direct light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
